Pyridoxal-5-Phosphate (P5P): Benefits, Side Effects & Dosage

Natural chemical reactions in your body occur all the time and are beneficial to your health and well-being. You’re alive because of the natural process of chemical reactions. Cooking food is a chemical reaction, and so is eating it. Taking supplements causes chemical reactions in your body, and so does the simple act of breathing. Pyridoxal-5-phosphate (P5P) plays an integral role in over one hundred natural chemical reactions that take place inside your body. For that reason, it’s an essential supplement.

What is Pyridoxal-5-Phosphate (P5P)?

Some reactions take place relatively easily, such as running, while others may need a push. Inside your body, that push happens when molecules called enzymes are present. (x) This is where P5P comes in to play. But P5P is a coenzyme. A coenzyme is a non-protein molecule that helps an enzyme do its job. An enzyme is a protein molecule that speeds up or slows down a chemical reaction in your body. A coenzyme cannot catalyze these reactions on its own but help get the enzymes working. (x) Think of a coenzyme as the thing that flips the switch and gets the chemical reaction rolling. P5P is the active form of Vitamin B6 — turns food into energy. (x)

P5P has many important jobs to perform in your body. For starters, it’s essential in processing macronutrients. These are nutrients required in large amounts of your diet: proteins, fats and carbohydrates. P5P also plays a role in producing chemical transmitters such as dopamine and serotonin and supporting new muscle growth and repair. It makes heme for hemoglobin, the protein that transports oxygen around the body. (x) (x) P5P also helps the body’s anti-inflammatory response. (x)

But P5P doesn’t stop there. It regulates nerve, heart and muscle function by keeping potassium and sodium levels balanced. (x) On its own and in combination with other enzymes, P5P works to break down chains of amino acids and reform them into other amino acids. (x) It assists with cell metabolism and releases energy as the body needs it. (x) It assists in synthesizing red blood cells and protective white blood cells or antibodies. (x)

Health Benefits of P5P

Now that you’ve read what P5P does for your body and have decided to take the supplement, make sure you first discuss it with your healthcare provider. Here is a more structured outline of its benefits:

  1. Vitamin B6 Deficiency

A P5P deficiency can cause problems in the nerves, skin and blood. Anemia (a lack of iron in your blood) is one possibility. (x) Signs of pyridoxine deficiency include diarrhea, rash and even dementia. (x) (xNausea and vomiting may also occur, leading to poor appetite and possibly malnutrition. Confusion, depression and anxiety are other potential indicators. (x) The American College for Advancement of Medicine reported that a deficiency in B6 and iron causes panic attacks and anxiety in their newsletter. The report stems from a human study performed in Japan, supporting low levels of B6 and iron results in anxiety and panic attacks. (x)

Low levels of P5P may cause peripheral neuropathy—pain, numbness and weakness around the body. Some other symptoms include insomnia, soreness on the tongue and irritability. (x) (x) (x)

Decreased immunity can become a problem with a deficiency of pyridoxine. (x) Children may experience a form of epilepsy if their bodies cannot metabolize Vitamin B6. (x) A P5P supplement may alleviate many or all of these symptoms and reverse a deficiency.

  1. Sideroblastic Anemia

Sideroblastic anemia is a group of blood disorders in which the bone marrow does not produce healthy red blood cells because of an inability to convert iron into hemoglobin. The iron accumulates in the red blood cells, creating a ringed sideroblast or a ringed nucleus in the cell. Symptoms include fatigue, weakness, trouble breathing, and an enlarged spleen and liver. Though you can inherit this health concern, other conditions can cause it as well, such as drug and toxin exposure. The cause may also be idiopathic or unknown. (x) In certain instances, a P5P supplement may help. According to a research study, the supplement helped alleviate the symptoms in a 72-year-old patient. (x)

  1. Homocysteine Blood Levels

High levels of the amino acid homocysteine mean potential risk factors for cardiovascular disease. (x) It stems from your body generating the amino acid methionine when you ingest meat, mainly. (x) Researchers have found a correlation between high homocysteine levels and heart disease. (x)

P5P supplements may reduce methionine levels in the body, reducing homocysteine levels at the same time. P5P may also help protect against high blood pressure (hypertension), coronary heart disease and cerebral vascular disease. (x)

  1. Cancer

A P5P deficiency may increase the risk for cancer of the cervix and pancreas. Studies show that many women with cervical cancer are deficient in Vitamin B6. (x) Researchers need to conduct more studies, but because there is a connection between the two, P5P supplements may reduce the risk for cervical cancer.

Pancreatic cancer is less common than other types, but it is very aggressive and kills an estimated 45,000 Americans in 2019. (x) One study further revealed that a full quarter of pancreatic cancer patients were deficient in Vitamin B6 and that subjects who consumed higher levels of Vitamin B6 — either from their diet or from supplements—had a reduced risk for pancreatic cancer. (x)

  1. Vision

Age-related macular degeneration (AMD) is an increasingly common disorder that causes vision loss, mainly in people older than 50. The macula is a small spot near the middle of the retina, which is necessary for clear central vision. AMD may progress slowly, or it may move fast. Studies claim that P5P supplements with other B vitamins may prevent vision loss from macular degeneration. (x)

  1. Arterial Health

Coronary heart disease is the number one killer in both men and women in the United States. It stems from plaque building up in the arteries. Atherosclerosis is a condition in which the arteries harden and lose flexibility. (x) According to research studies, B vitamin supplements, including P5P, may reduce the progression of early atherosclerosis. (x)

  1. Kidney Stones

Certain people have a higher likelihood of developing kidney stones because of a genetic disorder called type I primary hyperoxaluria. (x) Some research indicates that a B6 supplement with or without magnesium may decrease the risk of kidney stones for those with this inherited condition. (x) However, it’s vital to note that Vitamin B6 does not seem to help those who have developed kidney stones because of other causes.

  1. Nausea During Pregnancy

Studies suggest that taking Vitamin B6 in the form of pyridoxine may reduce nausea and vomiting for pregnant women. In fact, the American College of Obstetrics and Gynecology recommends Vitamin B6 first as a treatment for this complaint in early pregnancy. (x)

  1. Tardive Dyskinesia 

Tardive dyskinesia is a movement disorder in which the muscles of the face, neck, and limbs twitch involuntarily and interfere with the ability to communicate. It is a side effect of antipsychotic drugs used to treat schizophrenia — these drugs incapacitate you when you take them. Studies show that P5P supplements may help improve symptoms of this condition in some patients. However, the claim requires more research or avoid taking psychotropic drugs. (x)

  1. Aging

Glycation is a process in which sugar attaches to protein and forms harmful new molecules called advanced glycation end products (AGE). (xCataracts are one example of glycation; poor kidney function is another. (x) (x) AGEs can affect collagen production, causing premature aging. Wrinkled, sagging skin is one of the most visible signs. Studies suggest that Vitamin B6 may help protect against the glycation process and inhibit AGE formation. (x)

P-5-P Benefits

Side Effects of P5P

Vitamin B6 is a natural substance, and the body needs it to produce chemical reactions. It is also water-soluble, meaning the body releases it in urine. People rarely suffer from too much Vitamin B6 from food, but they can get too much of it in supplement form when taken for too long. (x) It may potentially cause headaches, nausea, vomiting and upset stomach. (x) Other side effects include skin rashes, nerve damage, sensitivity to light, heartburn and neuropathic pain. (x) (x

Where to Buy Pyridoxal-5-Phosphate (P5P)?

You can purchase pyridoxal-5-phosphate (P5P) at BulkSupplements.com. The company is an industry-leading manufacturer and distributor of pure dietary supplements. 

BulkSupplements.com is not just a consumer brand. It also supplies pure ingredients to other food and supplement brands to make their products. All products at BulkSupplements.com are manufactured and tested according to current and proper manufacturing practices.

Are you interested in trying pyridoxal-5-phosphate (P5P) for your health, as described in this article? Contact BulkSupplements.com to place an order today.

P5P Dosage

It’s always vital to consult with a doctor before adding any supplement to your health regimen, including P5P. The recommended dosage is 50 mg a day with meals unless a physician advises otherwise.

Why Take P5P?

Vitamin B6 is naturally in a variety of foods, including fish, liver, beef, starchy vegetables and non-citrus fruits. (x) However, food preparation may reduce vitamin levels. Cooking, canning, freezing and processing can destroy up to 50 percent of Vitamin B6. (x)

Also, the liver must convert Vitamin B6 to P5P before the body can use it. The liver converting B6 to P5P should not be a problem for those with a healthy liver, but compromised liver function can cause a deficiency. (x) Other vulnerable populations may include those with celiac disease and potentially autism, although researchers cannot confirm the relationship. (x) (x)

However, with a P5P supplement, the conversion process has already completed, and users experience the benefits faster. It can provide more physical energy, mental energy and better memory.

The Bottom Line

P5P is a coenzyme of Vitamin B6. A coenzyme helps enzymes catalyze chemical reactions in your body. It is integral to several different bodily functions, including metabolism, muscle growth and anti-inflammatory response. 

Studies show that P5P may help prevent the risk of heart disease and potentially cervical and pancreatic cancer. Vitamin B6 is also used to treat nausea in pregnancy and slow the skin’s aging process.

Insufficient P5P intake may cause a wide variety of health issues, including anemia, depression, irritability, lack of appetite and skin rashes. Although P5P may help treat or prevent health conditions, supplements are not a sufficient replacement for medical advice or treatment. Consult a doctor before adding P5P to your dietary routine.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Author: BulkSupplements Staff