L-Citrulline. Tune-Up Cardiovascular System & Sexual Performance

Updated: 1/4/24

In the fast-paced world we live in, it’s easy to neglect our bodies and overlook the importance of maintaining a healthy cardiovascular system. But what if I told you that there was a powerful amino acid that could help tune-up your heart and even enhance your sexual performance? Yes, you read that right. We’re talking about L-Citrulline – a natural supplement with numerous benefits for both men and women. So buckle up and get ready to learn all about this wonder nutrient that is gaining popularity among athletes, fitness enthusiasts, and individuals looking to improve their overall well-being.

What is L-Citrulline?

L-Citrulline is a non-essential amino acid that is naturally found in certain foods like watermelon, cucumbers, and pumpkins. It is also available in supplement form. This amino acid plays a significant role in the body’s nitrogen balance by converting into L-Arginine, another amino acid that helps improve blood flow and oxygen transportation in the body. L-Citrulline is known to increase nitric oxide production, which makes blood vessels widen, improving oxygen and nutrient delivery to the muscles.

When consumed, L-Citrulline converts to L-Arginine in the body. L-Arginine, in turn, activates the production of nitric oxide, a molecule that signals the blood vessels to relax and widen. This relaxation leads to an increase in blood flow, allowing oxygen and nutrients to reach the muscles more efficiently. Consequently, this leads to improved muscle function, reduced fatigue, and improved athletic performance.

L-Citrulline’s history and culture are fascinating. The amino acid gets its name from its first known source, watermelon. The name “Citrulline” comes from the Latin word “citrullus,” which means watermelon. The first time it was isolated was in watermelon juice by researchers in Argentina in 1914. Several decades later, research discovered more about L-Citrulline’s benefits, particularly in blood flow and muscle health. Since then, L-Citrulline supplementation has gained popularity amongst athletes, bodybuilders, and health enthusiasts worldwide.

What is Nitric Oxide?

When it comes to nitric oxide, it’s a molecule that is naturally produced by our bodies that helps to promote blood flow and blood vessel health. It-shows to help with immune function, brain health, and even sexual function. So, how are L-Citrulline and nitric oxide related? L-Citrulline actually converts into nitric oxide in the body. So, by consuming L-Citrulline, you can actually boost nitric oxide levels in your body and reap the associated health benefits.

Benefits of L-Citrulline Powder

Nitric oxide is a huge component of L-citrulline and therefore many of their potential benefits may go hand in hand. So what are the benefits of L-citrulline? The amino acid can naturally help widen the blood vessels, assisting with blood pressure and blood circulation. As a dietary supplement, L-citrulline powder may produce similar effects and help maintain health.

However, there is not a sufficient amount of medical evidence to claim that L-citrulline powder can cure or prevent any disease. If a patient decides to try the supplement, they should always get their doctor’s approval first.

May Improve Athletic Performance

If you’re someone who leads an active lifestyle or if you’re an athlete, you know that performance is everything. L-Citrulline powder has been shown in numerous studies to improve athletic performance by increasing blood flow, reducing muscle soreness and fatigue, and increasing endurance. These benefits make L-Citrulline powder a popular choice for athletes and fitness enthusiasts alike.

May Improve Cardiovascular Health

Your heart is one of the most important organs in your body, and it’s important to do everything you can to keep it healthy. L-Citrulline powder has been shown to help improve endothelial function, which can improve cardiovascular health and reduce the risk of heart disease.

Supports Erectile Function 

Did you know that L-Citrulline powder shows to improve erectile function in men? This is because L-Citrulline powder helps improve blood flow and circulation, which is one of the leading causes of erectile dysfunction. By increasing blood flow to the penis, L-Citrulline powder can help improve sexual performance and satisfaction.

May Boost Immune System Function

Your immune system is responsible for fighting off harmful invaders like bacteria and viruses. L-Citrulline powder shows to boost immune system function by increasing the production of nitric oxide, which can help prevent infections and improve overall immune function.

May Increase Nitric Oxide Production

L-Citrulline powder is a precursor to L-Arginine, which is an amino acid that triggers the production of nitric oxide in the body. Nitric oxide is a gas that helps dilate blood vessels, increasing blood flow throughout the body. This increased blood flow can help improve erectile function by allowing more blood to flow to the penis.

May Increase Energy Levels

If you’re someone who is constantly feeling sluggish, L-Citrulline powder may be able to help. This supplement shows to increase energy levels by increasing blood flow and improving overall circulation in the body. With consistent use, this supplement could help you feel more energized and awake throughout the day.

Support Muscle Growth

Whether you’re an athlete looking to gain muscle mass or simply looking to improve your overall physique, L-Citrulline powder can help support muscle growth. By increasing blood flow to the muscles, this supplement can help promote protein synthesis and muscle repair, leading to increased muscle mass and strength.

Benefits of L-Citrulline Powder

Side Effects of L-Citrulline Powder

Gastrointestinal Issues

One of the most common side effects of L-Citrulline powder is gastrointestinal discomfort. This can manifest in several ways, including stomach cramps, bloating, diarrhea, and flatulence. These are all a result of the powder increasing nitric oxide production in the body, which can cause inflammation in the gastrointestinal tract. The good news is that you can avoid these side effects by starting with a low dosage and gradually increasing it over time.


Another side effect of L-Citrulline powder is headaches. This is because the supplement boosts blood flow, which can cause tension in the head and neck muscles. This discomfort is usually short-lived and can be avoided by sticking to the recommended dosage. It’s also important to stay hydrated while taking the supplement, as dehydration can exacerbate headaches.

Low Blood Pressure

L-Citrulline powder shows to lower blood pressure, which is why it’s sometimes used to treat hypertension. However, if you already have low blood pressure, taking the supplement can cause it to drop to unhealthy levels. Symptoms of low blood pressure include dizziness, fainting, and nausea. To avoid this side effect, it’s important to monitor your blood pressure regularly and talk to your doctor before taking the supplement.

Allergic Reactions

Although rare, some people may experience allergic reactions to L-Citrulline powder. Symptoms of an allergic reaction include hives, itching, swelling, and difficulty breathing. If you experience any of these symptoms while taking the supplement, stop using it immediately and seek medical attention. It’s always a good idea to speak to your doctor before adding any new supplement to your routine, especially if you have a history of allergies.

Interactions with Medication

Finally, L-Citrulline powder may interact with some medications, including those for high blood pressure and diabetes. If you’re taking medication for any conditions, talk to your doctor before starting to take L-Citrulline powder. They’ll be able to advise you on whether it’s safe and how to incorporate it into your routine.

What is the Urea Cycle?

The urea cycle is a process in which the body converts toxic ammonia into urea, which is then excreted through the urine. L-Citrulline plays a key role in this process by converting into L-arginine, which then converts into nitric oxide. Nitric oxide plays a critical role in dilating blood vessels and increasing blood flow, which can help to reduce muscle soreness and improve overall workout performance.

Can You Take L-Citrulline & L-Arginine Together?

When taken separately, both L-Citrulline and L-Arginine shows to improve exercise performance and reduce muscle fatigue. However, when taken together, the benefits may be even greater. Combining L-Citrulline and L-Arginine can increase the production of nitric oxide, which can enhance blood flow to the muscles, improve nutrient delivery, and enhance recovery. In addition, taking these two supplements together can help reduce muscle soreness, increase muscle protein synthesis, and improve overall exercise performance.

While combining L-Citrulline and L-Arginine can provide many benefits, there are some potential risks to be aware of. For example, individuals who have low blood pressure or are taking medication for hypertension should consult with their physician before taking these supplements together. In addition, combining L-Citrulline and L-Arginine can cause gastrointestinal distress in some individuals, especially if taken on an empty stomach. To minimize the risk of side effects, it is important to start with a low dose and gradually increase it over a period of several weeks.

If you have an interest in taking L-Citrulline and L-Arginine together, there are several ways to do so effectively. One option is to take a pre-workout supplement that contains both L-Citrulline and L-Arginine, as well as other performance-enhancing ingredients like caffeine, beta-alanine, and creatine. Another option is to take these supplements separately, either in pill or powder form, and combine them into a single drink. No matter which option you choose, it is important to follow the recommended dosage instructions. Then, monitor your body’s reaction to the supplements.


As a dietary supplement, the recommended dosage for L-citrulline powder is 3,000 mg twice a day, or as directed by a physician. Remember to speak to a doctor before you consume any supplement. It may interfere with other medications or supplements or cause unwanted side effects.

Where to Buy L-Citrulline Supplements

You can purchase L-citrulline supplements in powder form at BulkSupplements.com. The company is an industry-leading manufacturer and distributor for pure dietary supplements. BulkSupplements.com is not just a consumer brand. It also supplies pure ingredients to other brands that distribute food and other supplement products. All products at BulkSupplements.com are manufactured and tested according to current and proper manufacturing practices.

Do you have an interest in trying L-citrulline supplements to potentially support cardiovascular health, maintain healthy circulation and improve exercise performance? Contact BulkSupplements.com to place an order today.



Bottom Line

They say a healthy gut means a healthy body, but so does having a healthy heart. Because L-citrulline plays a natural role in dilating the blood vessels it contributes to heart health by supporting healthy blood and oxygen flow throughout the body. The supplement derived from it may offer similar benefits. Although there is no scientific evidence that completely supports the supplement’s effects, some studies suggest possibilities.

The body already supplies L-citrulline on its own, but it is also in many fruits and vegetables. Its greatest strength is its natural role in nitric oxide production, which acts as a vasodilator. Nitric oxide is essential for heart health, but research also associates it with other conditions such as urea cycle disorders and erectile dysfunction. L-citrulline may also play a big part in protein synthesis to maintain muscle mass and maintaining healthy levels of ammonia.

Although it seems to have plenty of potential benefits, any supplement can cause side effects or interact with medications. To possibly avoid side effects, make sure to see a doctor before you take this supplement to ensure that it only benefits your health.

*** These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Author: BulkSupplements Staff