L-Citrulline DL-Malate

L-Citrulline DL-Malate. Increase Stamina & Recovery Time

Updated: 12/19/23

Are you tired of feeling exhausted during your workouts? Do you wish you could push through those last few reps with ease, or bounce back quickly after an intense training session? Well, my health-conscious friends, have I got a game-changer for you! Introducing L-Citrulline DL Malate, the secret weapon that will take your stamina and recovery time to new heights. This powerful supplement has been gaining buzz in the fitness community for its ability to enhance athletic performance and support the body’s natural recovery processes. Whether you’re a seasoned athlete looking to up your game or simply someone striving to get the most out of your fitness routine, keep reading to learn all about the incredible benefits of L-Citrulline DL Malate and how it can revolutionize your workouts. Trust me, you won’t want to miss out on this one!

What Is L-Citrulline DL Malate?

L-Citrulline DL Malate is a compound that is created by combining the amino acid L-Citrulline with malic acid. This compound is primarily in the fitness and health industries for its potential benefits, which include increasing energy, improving athletic performance, and reducing muscle soreness.

L-Citrulline, which is naturally in watermelon and other fruits, is to increase nitric oxide production in the body. Nitric oxide is a gas that helps to dilate blood vessels, which in turn can improve blood flow, increase endurance, and reduce fatigue. By combining L-Citrulline with malic acid, the resulting L-Citrulline DL-Malate is believed to be even more effective at increasing nitric oxide levels and improving athletic performance than L-Citrulline alone.

L-Citrulline DL-Malate has its origins in the world of bodybuilding and fitness. It was first introduced to the industry in the 1990s as a way to improve energy and reduce muscle soreness during and after workouts. Since then, its use has spread to other fitness and athletic communities, as well as to the general public.

Today, L-Citrulline DL-Malate is common in pre-workout supplements and energy drinks, as well as in some foods. It’s important to note that while some studies shows potential benefits of L-Citrulline DL Malate, more research is needed to fully understand its effects on the body and its potential risks.

What Is the Urea Cycle?

Our bodies are a finely tune machine that performs thousands of metabolic processes every moment. One such process that everybody needs to be aware of is the Urea Cycle. It plays an essential role in purifying your blood by eliminating ammonia while supporting your overall metabolism. We will focus on the fundamentals of the urea cycle so that you can gain more insight into your health and well-being.

The Urea cycle is the ornithine cycle, which takes place primarily in the liver cells. Its primary role is to remove excess ammonia, a toxic element produced during protein metabolism. As proteins break down, they’re converting into ammonia, which is then combined with carbon dioxide to form urea. The urea then releases into your bloodstream, transported to your kidneys, and then eliminated through your urine. The urea cycle is a complex process that involves several enzymes, which effectively breaks down all the protein you consume to ensure that it can be excreted from your body.

The Urea cycle starts with the conversion of ammonia into (N)-acetylglutamate by the enzyme, Carbamoyl Phosphate Synthase. After that, Ornithine combines with Carbamoyl Phosphate to form citrulline – which is then converted into Arginine, Agmatine, Proline, and Glutamic Acid. These metabolic conversions take place in several different steps, and each step requires a specific enzyme. The Urea cycle is a multi-factorial process that involves several organ systems such as the liver, kidneys, and lungs.

Benefits of L-Citrulline DL-Malate

May Enhance Athletic Performance

L-Citrulline DL-Malate is known to improve athletic performance because it increases the production of nitric oxide in the body. Nitric oxide relaxes the blood vessels, allowing for better blood flow to organs and muscles, thus enhancing physical performance. It also helps in reducing muscle soreness and fatigue, making it an ideal supplement for athletes and fitness enthusiasts.

May Boost Immune System

L-Citrulline DL-Malate helps in providing immunity to the body by preventing infections and harmful pathogens. It increases the production of white blood cells and promotes the activity of immune cells in fighting against diseases and infections. The supplement also acts as an anti-inflammatory agent and helps in reducing inflammation in the body. It amplifies the body’s defense system, thus making it less susceptible to illnesses.

May Reduce Blood Pressure

High blood pressure is a potential health risk that can lead to other health issues such as heart disease, stroke, and kidney disease. L-Citrulline DL-Malate is known to lower blood pressure levels by relaxing blood vessels, making it easier for blood to flow. It also increases the production of nitric oxide in the body, which acts as a vasodilator, leading to improved blood circulation and reduced blood pressure levels.

May Increase Nitric Oxide Production

Nitric oxide is a vasodilator, which means it relaxes the walls of blood vessels, resulting in increased blood flow. L-Citrulline DL-Malate is a precursor to nitric oxide, which means that it helps the body produce more nitric oxide. This increased blood flow can help improve endurance during workouts and reduce fatigue.

May Improve Muscle Protein Synthesis

Muscle protein synthesis is the process of building new muscle tissue. L-Citrulline DL-Malate shows to increase muscle protein synthesis, which means that it can help you build muscle faster. This is why it is popular among bodybuilders and fitness enthusiasts.

May Help Manage Urea Cycle Disorders

In fact, a study published in the Journal of Inherited Metabolic Disease found that citrulline supplementation improved ammonia detoxification in patients with various urea cycle disorders. Another study published in Molecular Genetics and Metabolism showed that citrulline supplementation was effective in preventing neurological damage in a mouse model of urea cycle disorder.

Helps Treat Anemia

L-Citrulline DL-Malate has been found to help treat anemia, a condition where the body doesn’t produce enough red blood cells or hemoglobin. By increasing red blood cell production, it can aid in improving oxygen delivery and overall energy levels.

May Reduce Toxins in the Body

Toxins can build up in the body from exposure to environmental pollutants, poor diet, and other factors. L-Citrulline DL-Malate has been found to help reduce toxins in the body by increasing the activity of enzymes responsible for eliminating toxins from the body.

May Enhance Intimate Performance

Studies show that L-Citrulline DL-Malate has the potential to increase drive and improve dysfunction. Nitric oxide, which is when L-Citrulline DL-Malate experiences consumption, dilates blood vessels in the genital area, leading to improving romantic performance. It also increases male hormones levels in men, thus providing more energy and stamina.

May Improve Brain Function

L-Citrulline DL-Malate also has positive effects on the brain function by improving cognitive function and reducing fatigue. It provides an energy boost to the brain, leading to better mental focus and alertness. Studies suggest that it also helps in enhancing memory and reducing anxiety levels.

L-Citrulline DL-Malate Benefits

Side Effects of L-Citrulline DL-Malate Supplements

Gastrointestinal Issues

It is not uncommon to encounter gastrointestinal issues when taking L-Citrulline DL-Malate supplements, especially when consumed on an empty stomach or a high dosage. Common symptoms include diarrhea, bloating, nausea, and stomach cramps. However, these symptoms tend to subside after some time and hardly persist. To avoid such complications, it is a recommendation to consume L-Citrulline DL-Malate with meals.


Nitric oxide boosters, including L-Citrulline DL-Malate, are known to lower blood pressure levels by widening blood vessels. As such, taking L-Citrulline DL-Malate in high doses can lead to lightheadedness, dizziness, and even fainting. If you experience any of these symptoms while taking L-Citrulline DL-Malate, it is essential to lower or stop your intake immediately.

Allergic Reactions

Allergic reactions to L-Citrulline DL-Malate are rare. However, if you develop any adverse symptoms such as swelling, hives, and difficulty breathing, you should consult your doctor right away.

Other Possible Side Effects

Some individuals have reported other potential side effects from taking L-Citrulline DL-Malate, such as headaches, tinnitus (ringing in the ears), and insomnia. Although these side effects are rare, they can occur in some people.

Interaction with Medications

If you’re taking any medications, it’s important to talk to your doctor before using L-Citrulline DL-Malate. The supplement can interact with certain drugs, including nitrates, antihypertensive medications, and erectile dysfunction drugs. Combining L-Citrulline DL-Malate with these drugs can lead to dangerous drops in blood pressure and other serious health problems. Always consult with a healthcare professional before starting any new supplement or medication regimen.

L-Citrulline DL Malate vs. L-Citrulline

It is a combination of L-citrulline and malic acid. The malic acid adds to help with absorption and to enhance energy production. This form of L-citrulline is often in use in pre-workout supplements, as it can help to improve endurance and reduce fatigue. It can also be helpful for those who are trying to build muscle, as it can promote faster recovery.

L-citrulline on its own is a more straightforward version of the amino acid. It’s often in use to improve athletic performance, particularly in high-intensity exercise. It can help to reduce the buildup of ammonia in the muscles, which can lead to fatigue. It shows to improve blood flow to the muscles, which can enhance recovery and promote muscle growth.

So, which form of L-citrulline is best for you? It really depends on your goals and what you’re looking for in a supplement. If you’re focusing on improving endurance and reducing fatigue, L-citrulline DL-malate may be your best bet. On the other hand, if you’re looking for a more straightforward approach to improving athletic performance, L-citrulline on its own may be a better choice.

How to Take L-Citrulline DL-Malate

You may be wondering when to take L-citrulline DL malate and how often. That depends on the supplement and the advice from your healthcare provider. The recommended serving size for BulkSupplements L-Citrulline DL-Malate 1:1 Powder and  L-Citrulline 2:1 Pure Powder is 3,000 mg twice a day. 

The United States Food and Drug Administration does not regulate supplements. Before consuming any supplements, check with your doctor, dietician or nutritionist for approval. They are constantly training and have more experience and may be more familiar with your health and fitness history in order to better advise you.

Where to Buy L-Citrulline DL-Malate 

You can purchase L-Citrulline DL Malate supplements in powder form at BulkSupplements.com. The company is an industry-leading manufacturer and distributor for pure dietary supplements. BulkSupplements.com is not just a consumer brand. It also supplies pure ingredients to other brands that distribute other food and supplement products. All products at BulkSupplements.com are manufactured and tested according to current and proper manufacturing practices.

Do you have an interest in trying L-Citrulline DL malate supplements to help you improve exercise endurance, reduce fatigue, reduce toxin buildup and absorb nutrients more efficiently? Contact BulkSupplements.com to place an order today.





Bottom Line

It combines the amino acid L-citrulline and the naturally-occurring compound malate or malic acid. The result is a powerful dietary supplement because the malate may successfully increase the benefits that L-citrulline provides, besides adding its own. Key potential benefits: prolonged endurance, reduced fatigue and toxin buildup and quicker muscle recovery during workouts. L-citrulline DL malate may support overall cardiovascular and cognitive health too!

Though it’s safe to use, beware of the supplement’s potential to interact with certain medications and the lack of information regarding its effects during pregnancy and breastfeeding. Remember to always consult your healthcare provider for diagnoses, accurate medical information and permission before taking any supplements.

**These statements have not had an evaluation by the Food and Drug Administration. These products are not intentionally to diagnose, treat, cure or prevent any disease.

Author: Ryan Quigley
Graduate of Longwood University in Virginia. Part-time sports journalist covering the Vegas Golden Knights.