Nattokinase. Powerful Enzyme Supports Healthy Blood Flow & Immunity

Updated: 12/22/23

Nattokinase. You’ve probably heard mention of this powerful enzyme but perhaps wondered what it actually is and if it could benefit you. As a health conscious individual, you’re always on the lookout for natural substances that support overall wellness. Well wonder no more – nattokinase is here to share its secrets! This unique enzyme produced during the fermentation of soybeans has some seriously impressive properties to support cardiovascular and immune health. From promoting healthy blood flow to helping break down excess fibrin, nattokinase packs a punch. Curious to learn more about how this amazing enzyme works its magic? Then pull up a seat my friend and let me share what I’ve learned about nattokinase and how adding it to your supplement routine could be a game changer for your health.

What is Nattokinase

Nattokinase is a type of enzyme that is derived from natto. Natto is a traditional Japanese food from fermenting soybeans that boil, coating in special bacteria, and aging for up to a week. When this process is complete, a sticky consistency is an achievement, with a strong aroma and a unique taste. But more importantly, this process creates nattokinase, a proteolytic enzyme that is found abundantly in natto.

Nattokinase is a clot-busting enzyme that can help prevent cardiovascular diseases. It works by breaking down fibrin, a protein that forms clots and can lead to harmful blood clots if not dissolved. By breaking down fibrin, nattokinase can prevent blood clots from forming, which reduces the risk of heart attacks and other related health issues. In addition, nattokinase is also believed to help reduce high blood pressure and cholesterol levels in the body.

Nattokinase has been used in Japan for centuries as a medicinal food due to its remarkable healing properties. In the 1980s, researchers started to study nattokinase in a clinical setting, and the results have been extremely promising. 

Natto has been an important dietary staple in Japan for centuries, dating back to a time when Japan was isolating from the rest of the world. It was a superfood that provides a good source of protein and other vital nutrients. Natto was also a belief to have medicinal properties, and was in use to treat various health issues, from heart disease to digestive problems. To this day, natto is still a vital part of the Japanese diet and culture.

Nattokinase Benefits

Improves Cardiovascular Health

Nattokinase has several benefits for your heart health. It can act as a natural blood thinner, reducing the risk of blood clots, strokes, and heart attacks. It can also help lower high blood pressure, which is a major contributor to heart diseases. Nattokinase can reduce cholesterol levels and improve blood circulation, keeping your heart in good health.

May Help in Blood Clot Prevention

Blood clots can be potentially life-threatening, and nattokinase can help prevent them from forming. When taken regularly, it acts as a natural blood thinner, reducing the likelihood of blood clots that may lead to blockages in the arteries. It also helps to dissolve existing clots, which is especially helpful for those at high risk of arterial blockages.

Anti-Inflammatory Properties

Nattokinase has been shown to have powerful anti-inflammatory properties thanks to its ability to convert plasminogen into plasmin. Plasmin is an enzyme that helps to break down fibrin, a protein that is in clotting. By breaking down fibrin, nattokinase can help to reduce inflammation throughout the body.

May Improve Circulation

Nattokinase has been found to improve circulation by promoting the production of nitric oxide, a molecule that helps to relax blood vessels. This relaxation allows for increased blood flow throughout the body, which can lead to improved overall health.

May Improve Skin Health

Nattokinase has been found to have anti-aging properties, making it a valuable nutrient for individuals who are looking to maintain youthful-looking skin. By improving circulation and reducing inflammation, nattokinase can help to promote healthy, glowing skin.

May Provide Relief for Joint Pain and Inflammation

Nattokinase contains anti-inflammatory properties that can help relieve joint pain and inflammation. It can be helpful for those who suffer from arthritis and other joint-related issues. Its anti-inflammatory properties help reduce swelling and increase mobility, leading to improved joint health.

May Boost Digestive Health

Nattokinase contains fiber, which is beneficial for maintaining good digestive health. It can help regulate bowel movements, reduce constipation and other digestive problems. Fiber can also promote healthy bacteria in the gut, improving overall gut health.

May Enhance Brain Function

Nattokinase contains vitamin K, which has various benefits for your brain health. Vitamin K can help enhance cognitive function and brain health. It’s also essential for blood clotting and maintaining healthy bones.

Nattokinase Infographic

Nattokinase Side Effects


Since it is a natural blood thinner, it can cause excessive bleeding. This is particularly true for those who are already taking blood-thinning medications such as aspirin or warfarin. It’s best to consult with a medical professional before taking nattokinase if you have any issues with blood clotting.

Allergic Reactions

In some instances, nattokinase can cause allergic reactions such as skin rashes, hives, swelling of the lips, tongue, or throat, and difficulty breathing. If you experience any of these symptoms, seek medical attention immediately.

Digestive Issues

It can also cause digestive upset such as diarrhea, nausea, or vomiting. These side effects may be due to the high levels of vitamin K2 present in nattokinase.


Some people have also reporting experiencing headaches after taking the supplements.

Interference with Medications

It can also interact with other medications such as blood pressure medications, anti-inflammatories, and antibiotics.

Dosage and Instructions

The appropriate range of doses for nattokinase depends on your individual usage and ailment, however, nattokinase supplements should be taken in 100 mg servings at a maximum of three times a day. The best way to ensure the proper dosage is to use a milligram scale, 1/32 of a teaspoon is 89 milligrams, while just over that will be 100 mg.

Nattokinase & Serrapeptase

Serrapeptase is another enzyme that is produced by bacteria, and has been used for its anti-inflammatory and pain-relieving properties. It works by breaking down proteins in the body, particularly those that contribute to inflammation and pain. Like nattokinase, serrapeptase has been studied for its potential cardiovascular benefits, as well as its ability to reduce swelling and inflammation in the body, making it a popular choice for those with chronic pain, arthritis, and other inflammatory conditions. Serrapeptase is also typically in capsule form, and is safe for most people, although those with bleeding disorders or digestive issues should exercise caution.

While both nattokinase and serrapeptase are enzymes that can benefit cardiovascular health, they work in different ways. Nattokinase is specific to breaking down fibrin, while serrapeptase is more focusing on reducing inflammation in the body. As a result, it is often for those with a history of blood clots or cardiovascular disease, while serrapeptase may be more helpful for those with chronic pain or inflammatory conditions. Both supplements are safe for most people, but as with any supplement, it is important to talk to your healthcare provider before starting them, particularly if you are taking any medications or have underlying health conditions.

Where to Buy Nattokinase

Get your Nattokinase fix at! They’re the go-to source for pure dietary supplements. Not only do they create their own top-notch products, but they also supply high-quality ingredients to other brands in the food and supplement industry. Rest assured that all their products follow strict manufacturing practices. Ready to give Nattokinase a try? Don’t wait and order from today!


The Bottom Line

We all admit that heart disease is one of the most critical health issues, and taking care of your heart should be a top priority. Understanding the benefits of Nattokinase, a natural supplement with proven health benefits, can be the first step to achieving optimal heart health. The combination of all these benefits, such as reducing cholesterol levels, regulating blood pressure, improved circulation, and anti-clotting properties, makes it a remarkable supplement that everyone should consider adding to their supplement routine. Invest in yourself today, and ensure that your heart health is well protected.

Overall, nattokinase supplements are safe for most people when you take as per directions. However, as with any supplement or medication, there is a risk of side effects. By following the recommended dosage and talking to your healthcare provider before taking supplements, you can minimize your risk of experiencing any negative side effects.

If you experience any severe side effects after taking it, stop taking the supplement and seek medical attention immediately. By prioritizing your health and safety, you can experience the potential benefits of nattokinase without any negative repercussions.

These statements have not been evaluated by the Food and Drug Administration. These products and statements are not intended to diagnose, treat, cure or prevent any disease.

Author: Ryan Quigley
Graduate of Longwood University in Virginia. Part-time sports journalist covering the Vegas Golden Knights.