Fisetin Supplements. Maximize Endurance, Power, and Cognitive Function

Updated: 11/16/23

Are you looking to get the most out of your workouts and cognitive function? Fisetin supplements may be just what you need. Not familiar with Fisetin? It’s a naturally occurring antioxidant that is often found in plants such as strawberries, apples, onions, persimmons, and other fruits and vegetables. Research shows that it increases endurance and muscle power, while also having several potential benefits for brain health. This amazing supplement is gaining traction among those who are health-conscious as they seek ways to supercharge their physical performance and optimize their mental well-being. Read on to learn more about how Fisetin can affect your body in positive ways!

What is Fisetin Supplement?

What if I told you there was a molecule that could help you live longer, improve your memory, and even prevent cancer? Sounds too good to be true, right? Well, it’s not. That molecule is called fisetin, and it’s one of the most powerful anti-aging compounds in the world.

Fisetin is a plant-based flavonoid compound that is found in many fruits and vegetables including apples, strawberries, and onions. It’s becoming increasingly popular in anti-aging formulations because of its ability to reduce inflammation, increase antioxidant levels, and provide protection against oxidative stress. What does that mean for your skin? It means that Fisetin helps to maintain healthy cells, elastic skin, and fewer wrinkles over time.

Sounds like a foreign language right? Most of us have never heard of fisetin before. It’s not catchy, and it’s not any food that we can easily recognize. But surprisingly, it’s in most of the foods we love and know. Fisetin is an antioxidant that can be found in all kinds of fruits, veggies and nuts in varying amounts (x, x). This compound can helprelieve inflammatory conditions, reduce oxidative stress and regulate the growth of our heart cells.

Benefits of Fisetin

Fisetin not only helps improve our immune system and prevent hyperdrive, we also know this nutrient helps protects the health of our nerves, though we aren’t quite sure how it does that.

Fisetin has been seen in the laboratory to have direct effects on our cells. It interacts with proteins on our cell membrane and regulates the ions that move in and out. These ions play a big role, and can influence the process of aging and even propagate diseases like cancer and diabetes. The regulation of these ion movements can also have a huge impact on the health of our nerves. In the lab, this small but mighty molecule has demonstrated effects that heal nerves, fight cancer and soothe inflammation.


As we age, our bodies start to break down and become less efficient, which can lead to a range of health issues. However, fisetin shows to have powerful anti-aging properties that can help to slow down this process. Fisetin helps to activate specific proteins that are responsible for repairing damaged cells, reducing inflammation, and regulating cellular processes. This leads to healthier, younger-looking skin, improved muscle function, and stronger bones.

Plant flavonoids like fisetin helps slow down senescence. It’s thought that it does this by stabilizing membrane proteins to help red blood cells from dying. It also helps reverse some of the DNA damage in our aging cells. With less DNA damage, cells grow and replicate. All of these effects can help us prevent many age-related diseases, such as osteoporosis, heart disease and the general frail-ness of old-age. Though all flavonoids have powerful effects against aging, it’s been a suggestion in experiments that fisetin is the strongest anti-aging compounds of them all.

Anti-Inflammatory Properties

Inflammation is at the root of almost all chronic diseases, from arthritis to heart disease. However, fisetin has been shown to have powerful anti-inflammatory properties. It can reduce inflammation throughout the body, which can help to prevent a range of health issues. This means that fisetin can be to treat everything from joint pain to allergies.

Antioxidant Properties

First and foremost, Fisetin is a potent antioxidant. As you know, antioxidants are critical to fighting off free radicals that can cause damage to cells and DNA in your body. Not all antioxidants are created equal, and Fisetin surpasses others like Vitamin C and E in various ways. Fisetin can enter the brain where it shows to help protect neurons from inflammation and oxidative stress, which can lead to Alzheimer’s and other brain conditions.

Improved Brain Function

As we age, our brain function can start to decline. This can lead to memory loss, decreased cognitive abilities, and even dementia. However, research has shown that fisetin can help support and improve brain function. Studies have found that fisetin is able to reduce inflammation and oxidative stress in the brain, which in turn helps to protect and improve cognitive function. Fisetin also stimulates the production of brain-derived neurotrophic factor (BDNF), a protein that helps to promote healthy brain cells. This special nutrient found in our everyday berries and vegetables can help us protect ourselves from diseases like Parkinson’s or Alzheimer’s.

Regulates Blood Sugar

Fisetin can also help people suffering from diabetes in many different ways. Though research is limited, one study on diabetic rats found that month-long supplementation with fisetin lowered blood sugar levels. Scientists aren’t sure how it works, but it’s possible that fisetin helps regulate sugar production in the liver. Other studies have also mentioned preventative effects against diabetes-related damage to the kidneys, nerves and the heart. Fisetin supplementation also appears to help increase insulin secretion in diabetic rats.

Fights Cancer

Fisetin fights cancer from multiple different angles. Cancer is one of the most frightening diseases we can face, and unfortunately, it’s becoming more common every year. However, fisetin shows to have powerful anti-cancer properties. It’s able to inhibit the growth of cancer cells, reduce inflammation in the body, and improve the body’s natural cancer-fighting abilities. Fisetin shows to protect healthy cells from the damaging effects of chemotherapy and radiation.

Cardiovascular Health

Heart disease is one of the leading causes of death worldwide, and it’s becoming more prevalent every year. However, fisetin shows to have a range of benefits when it comes to  cardiovascular health. Fisetin can reduce inflammation and oxidative stress, which can help to lower blood pressure, improve circulation, and reduce the risk of heart disease. Fisetin has also been shown to improve endothelial function, which is vital for maintaining healthy blood vessels.

Promotes Healthy Skin

Fisetin’s antioxidant properties come in handy for skin health too. Research suggests that the flavonoid can protect the skin from harmful UV rays and reduce the visible signs of aging. It can also help reduce hyperpigmentation, decrease wrinkles and fine lines, and improve skin elasticity. 

Benefits of Fisetin

Fisetin in Foods

You can find fisetin in many different regular foods like nuts, veggies and even wine. However, to get the biggest dose naturally, you’d have to eat a ton of strawberries. Strawberries are one of the best sources of foods with fisetin. It’s got 6 times the level of it in apples, and 16 times more than that in persimmons, which are second and third runner-ups in terms of foods.

Food list is below:

  • Strawberries
  • Apples
  • Grapes
  • Persimmons
  • Kiwifruit
  • Onions
  • Cucumbers
  • Mangoes
  • Tomatoes
  • Peaches

When to Take Fisetin

Fisetin supplements are usually visible in the form of capsules and are best with meals. The ideal time of day to take it is in the morning after breakfast. It is becauseit can help improve cognitive function and energy levels. Fisetin can enhance memory and the ability to process complex tasks, which helps fight brain fog and fatigue. It can also help regulate the circadian rhythm, which is vital in maintaining body rhythms, aiding restful sleep, and improving sleep quality.

Fisetin and Quercetin

These two supplements are two antioxidants that offer numerous health benefits beyond just reducing oxidative stress. Fisetin may help with age-related cognitive decline, cancer, and diabetes, while quercetin may boost immune function, reduce inflammation, and support cardiovascular and cognitive health. Supplementation is key to getting enough of these powerful compounds, so consider adding these flavonoids to your daily supplement regimen. With the right balance of antioxidants, you can keep your body healthy and vibrant at any age.

Side Effects of Fisetin

Blood Thinning

One of the potential side effects is that it can increase bleeding time and reduce blood clotting. This means that if you are taking other drugs that affect blood clotting, such as aspirin, ibuprofen, or warfarin, taking fisetin may increase your risk of bleeding and bruising. Therefore, if you are on any medication that affects your blood, it is essential to consult with your doctor before you start taking it.

May Interact with Medications

Fisetin can interact with other medications, including but not limited to statins, anticancer drugs, and immune suppressants. This means that it can interfere with their effectiveness, cause unexpected side effects or increase the risk of toxicity. Hence, it is important to let your doctor know if you are taking any medication before you start using fisetin.

Gastrointestinal Distress

Some people may experience stomach discomfort, nausea, diarrhea, or constipation when taking fisetin supplements. This is because it can affect the digestion and absorption of other nutrients and can disrupt the balance of the gut bacteria. To avoid gastrointestinal distress, it is a recommendation to start with a low dose and gradually increase it over time or take it with food.

May Interfere with Fertility

Fisetin can affect reproductive hormones, and follicle-stimulating hormone, which may have adverse effects on fertility. In a recent study on male rats, taking fisetin reduced sperm count, motility, and viability. Hence, if you are trying to conceive or are pregnant, it is advisable to avoid supplements or consult with your doctor before you start taking them.

Allergic Reactions

Like any other supplement, it can cause allergic reactions in some people. Symptoms of allergic reactions may include hives, itching, swelling, difficulty breathing, or anaphylaxis, which can be life-threatening. Therefore, if you experience any of these symptoms after taking fisetin, stop using it immediately, and seek medical attention.

Liver Function

One of the potential side effects of fisetin is that it may negatively impact liver function. While studies have been conducted on mice and not humans, it’s still important to be aware of this potential risk. In one study, it increased liver damage in mice, and another study found that high doses causes liver toxicity in rats. If you have any pre-existing liver conditions, it’s particularly important to speak with a healthcare professional before taking fisetin supplements.

The Bottom Line

Fisetin is a powerful antioxidant that has numerous health benefits. However, it is essential to be aware of the potential side effects of taking this supplement, especially if you are on any medication or have a pre-existing medical condition. To reduce the risk of adverse effects, it is advisable to start with a small dose and consult with your healthcare provider before you start taking it. Remember, a healthy lifestyle, including a balanced diet, regular exercise, and stress management, is essential in maintaining optimal health and well-being.

Fisetin is a powerful compound in certain fruits and vegetables that offer numerous health benefits. It’s a great way to enhance your diet while reducing inflammation and promoting healthy cell growth. By adding enriched foods to your daily diet, you can boost your nutritional intake and improve your overall wellbeing. However, it’s crucial to use it in moderation and to consult with a doctor before taking supplements. So, include fisetin into your diet today and take one step closer to a healthier lifestyle.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease

Author: Ryan Quigley
Graduate of Longwood University in Virginia. Part-time sports journalist covering the Vegas Golden Knights.