L-Pyroglutamic Acid

L-Pyroglutamic Acid. Prevent Brain Damage and Boost Your Memory

Updated: 12/29/23

Have you ever found yourself frustrated, struggling to recall facts and information you knew you learned? We’ve all experienced those “senior moments” now and then. But did you know there may be a simple dietary approach that could help supercharge your memory and protect your brain as you age? A growing body of research is showing that a little-known amino acid called L-pyroglutamic acid (LPA) plays a key role in brain health and may help prevent cognitive decline. What is this mysterious LPA, and how can adding it to your diet support your memory and overall brain function? Let’s explore what science is revealing about the neuroprotective powers of LPA.

What is L-Pyroglutamic Acid?

L-Pyroglutamic Acid, also as pyroglutamic acid, is a naturally occurring amino acid in high concentrations in the brain. It is classified as a neurotransmitter – a chemical messenger that helps communicate brain signals. The precise functions of LPA are still not fully understood, but it is believed to play a critical role in cognitive processes such as memory and learning. While LPA is synthesized naturally in the brain, it can also be obtained through dietary sources such as fruits and vegetables.

LPA is famous for regulating the flow of neurotransmitters and other important chemicals in the brain. It is thought to enhance brain function by increasing the synthesis of acetylcholine – a neurotransmitter that is essential for memory and learning. Additionally, LPA has been shown to reduce stress levels, improve mood and increase overall energy levels – all of which can contribute to improving cognitive function.

LPA has a long history of use in traditional medicine practices. It has been used in Asia for centuries as an herbal remedy to boost energy, improve memory and reduce stress. Traditional Chinese medicine practitioners also use LPA to help alleviate symptoms of anxiety and depression. Today, LPA is widely available in Western countries as a dietary supplement.

Glutamine: Parent of L-Pyroglutamic Acid

Pyroglutamic acid comes from the most plentiful amino acid in the human body: glutamine. Glutamine is a busybody chemical, facilitating more metabolic processes than any other amino acid in the body.

Glutamine is one of the most abundant amino acids in the body. It plays a critical role in repairing and rebuilding muscles after a hard workout. Additionally, glutamine aids in gut health by helping to improve the lining of the intestines and protecting against leaky gut syndrome. It also possesses anti-inflammatory properties, which can help reduce swelling and pain in the body. Glutamine can be in various foods, such as beef, poultry, fish, dairy, and eggs, but it can also be taken as a supplement. Glutamine builds proteins, helps maintain body pH and plays a key role in DNA synthesis. It’s also an ingredient in the important antioxidant glutathione.

Glutamine also:

  • Helps replenish glycogen in the muscles after intense exercise
  • Maintains the mucosal gut lining
  • Improves immune function
  • Increases muscle mass
  • Serves as the main source of energy for some immune cells
  • Acts as an emergency source of energy when blood levels of glucose fall

Glutamine is one of 20 naturally-present amino acids in protein. It’s in high levels in eggs and in meat products. It’s also abundant in whey and casein proteins.

Glutamine is a key immune system booster and also benefits digestive health. Both your immune system and your GI tract often use glutamine for fuel instead of glucose.

But what about L-pyroglutamic acid? This nutrient is an analog of glutamine, meaning it is from glutamine and has similar properties. L-pyroglutamic acid shows to enhance memory and cognition by boosting levels of neurotransmitters in the brain. It can also help to reduce anxiety and stress levels, making it a popular supplement among those who lead busy and stressful lifestyles.

L-Pyroglutamic Acid Benefits

Excellent Nootropic

L-Pyroglutamic Acid is an excellent nootropic that can boost cognitive function, improve memory and learning, enhance mood, and increase motivation. It’s a safe and well-tolerated supplement that can be taken on its own or combined with other nootropics for a more comprehensive cognitive support supplement.

May Sharpen Mental Clarity

L-Pyroglutamic Acid is known to support cognitive function, particularly by enhancing memory recall and brain performance. It can increase neurotransmitter activity in our brain, which helps in better information processing, problem-solving, and decision-making. Additionally, it can reduce stress levels that can significantly affect our mental clarity.

Improves Memory and Learning

L-Pyroglutamic Acid is a natural chemical compound in our brains. Several clinical studies have shown that L-PGA supplementation can significantly improve memory and learning ability. It is a belief that L-PGA acts as a neurotransmitter and enhances communication between brain cells, leading to better synaptic plasticity and memory consolidation.

May Boost Energy Levels

L-Pyroglutamic Acid can support physical performance by boosting energy levels. It stimulates the conversion of glucose into ATP, which is the energy source of our cells. Therefore, it can help us endure during physical activities, especially in sports and workouts. It can also reduce fatigue and help us maintain our focus and concentration.

May Regulate Mood and Sleep

In addition to reducing stress and anxiety, LPA has also been found to regulate mood and sleep. A study on rats found that LPA can help improve sleep quality and duration. Another study on humans showed that supplementing with LPA can help reduce symptoms of depression.

May Reduce Stress

Chronic stress can have severe consequences on the mind and body, resulting in physical and emotional exhaustion. However, L-Pyroglutamic Acid can help alleviate stress and its symptoms. It aids in the production of GABA (gamma-aminobutyric acid), which helps reduce stress levels, promotes relaxation and helps bring about a sense of calm.

Supports Skin Health

L-PGA has also been found to have beneficial effects on skin health. It is to promote collagen production, which helps to improve skin elasticity and reduce wrinkles. It also acts as an antioxidant, protecting skin cells from damage caused by free radicals.

May Protect Your Brain Against Oxidative Stress

L-PGA is also a powerful antioxidant, which means it can help protect your brain and body against damage from free radicals. Free radicals are unstable molecules that can damage brain cells, leading to cognitive decline and other health problems. By neutralizing these free radicals, L-PGA can help protect your brain and keep you sharp as you age.

Anti-aging Properties

As we age, our bodies experience a decline in cognitive function, energy levels, immune function, and other essential bodily processes. L-Pyroglutamic Acid can help slow down this process by providing antioxidant protection, promoting healthy mitochondrial function, and by aiding in neurotransmitter production. This leads to healthier brain function, improved energy levels, and overall health.

Supports Immune System

L-Pyroglutamic Acid can support our immune system by stimulating the production of immune cells. It can also increase the activity of natural killer cells, which help in fighting viruses and tumors. Furthermore, it can help in reducing inflammation, which is the root cause of many chronic diseases.

L-Pyroglutamic Acid benefits infographic

L-Pyroglutamic Acid Side Effects


One of the most common L-Pyroglutamic acid side effects is headaches. This is because PCA can increase glutamate levels in the brain, which can cause overstimulation and lead to headaches. If you’re prone to migraines or headaches, it’s best to start with a lower dose and gradually increase it over time. Alternatively, you can try a different nootropic with a lower risk of headaches.


Some people may experience nausea when taking L-Pyroglutamic acid. This is because of an increase in glutamate levels, which can affect the digestive system. If you experience this side effect, try taking your supplement with food or reducing your dosage.


L-Pyroglutamic acid can also disrupt sleep patterns and lead to difficulty sleeping. This is because the amino acid can increase brain activity and keep you alert. To avoid this side effect, take your supplements earlier in the day and avoid taking them close to bedtime.

Anxiety and Nervousness

Another L-Pyroglutamic acid side effect is increased anxiety and nervousness. This is because of the increased glutamate levels, which can stimulate the nervous system. If you’re prone to anxiety, you may want to avoid this supplement altogether.

Allergic Reaction

In rare cases, some people may experience an allergic reaction to L-Pyroglutamic acid. Symptoms can include hives, difficulty breathing, and swelling of the face or throat. If you experience these symptoms, stop taking the supplement immediately and seek medical attention.


You can find pyroglutamic acid supplements in capsule form or in nootropic complexes.

You can also mix pyroglutamic acid powder into a customized preworkout focus blend. As a dietary supplement, take 1,000 milligrams up to three times daily, or as directed by your physician. For best results, take pyroglutamic acid between meals.

Some people take 100 mg up to three times daily. Take as directed on the supplement package. Pregnant or lactating women, people with diabetes, hypoglycemia and people with known medical conditions and/or taking other supplements or drugs should consult a health practitioner. Additionally, young children or people who take blood thinners like Coumadin and Aspirin should not ingest pyroglutamic acid supplements.

Where to Buy L-Pyroglutamic Acid

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The Bottom Line

If you’re looking to boost your brainpower, L-Pyroglutamic Acid is an excellent supplement to consider. By increasing neurotransmitters’ levels, LPA can help improve memory, focus, mood, and overall cognitive function. However, always remember to consult your doctor before taking any supplements, and start with lower doses to monitor any side effects. With all these in mind, give L-Pyroglutamic Acid a trial and take a step forward to achieve top-notch brain health.

L-Pyroglutamic acid can be a beneficial supplement for many people who want to enhance their cognitive function and memory. However, as with any supplement, it’s essential to be aware of the potential side effects. Headaches, nausea, insomnia, anxiety, and allergic reactions are all possible side effects of L-Pyroglutamic acid. If you experience any of these symptoms, it’s essential to talk to your doctor and adjust your dosage or switch to a different nootropic. As always, it’s essential to consult your healthcare professional before starting any supplement regimen.

These statements have not been evaluated by the Food and Drug Administration. These products and statements are not intended to diagnose, treat, cure or prevent any disease.

Author: Ryan Quigley
Graduate of Longwood University in Virginia. Part-time sports journalist covering the Vegas Golden Knights.